RhoA/ROCK Signaling and Pleiotropic α(1A)-Adrenergic Receptor Regulation of Cardiac Contractility

AIMS: To determine the mechanisms by which the α(1A)-adrenergic receptor (AR) regulates cardiac contractility. BACKGROUND: We reported previously that transgenic mice with cardiac-restricted α(1A)-AR overexpression (α(1A)-TG) exhibit enhanced contractility but not hypertrophy, despite evidence impli...

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Detalhes bibliográficos
Main Authors: Yu, Ze-Yan, Tan, Ju-Chiat, McMahon, Aisling C., Iismaa, Siiri E., Xiao, Xiao-Hui, Kesteven, Scott H., Reichelt, Melissa E., Mohl, Marion C., Smith, Nicola J., Fatkin, Diane, Allen, David, Head, Stewart I., Graham, Robert M., Feneley, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053326/
https://ncbi.nlm.nih.gov/pubmed/24919197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099024
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