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Genomic scars as biomarkers of homologous recombination deficiency and drug response in breast and ovarian cancers
Poly (ADP-ribose) polymerase (PARP) inhibitors and platinum-based chemotherapies have been found to be particularly effective in tumors that harbor deleterious germline or somatic mutations in the BRCA1 or BRCA2 genes, the products of which contribute to the conservative homologous recombination rep...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4053155/ https://ncbi.nlm.nih.gov/pubmed/25093514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3670 |
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