Genomic scars as biomarkers of homologous recombination deficiency and drug response in breast and ovarian cancers

Poly (ADP-ribose) polymerase (PARP) inhibitors and platinum-based chemotherapies have been found to be particularly effective in tumors that harbor deleterious germline or somatic mutations in the BRCA1 or BRCA2 genes, the products of which contribute to the conservative homologous recombination rep...

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Detalles Bibliográficos
Main Authors: Watkins, Johnathan A, Irshad, Sheeba, Grigoriadis, Anita, Tutt, Andrew NJ
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2014
Assuntos:
Review
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053155/
https://ncbi.nlm.nih.gov/pubmed/25093514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3670
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