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Persistence of Gut Mucosal Innate Immune Defenses by Enteric α-Defensin Expression in the Simian Immunodeficiency Virus Model of AIDS
Gastrointestinal mucosa is an early target of HIV and a site of viral replication and severe CD4+ T-cell depletion. However, effects of HIV infection on gut mucosal innate immune defense have not been fully investigated. Intestinal Paneth cell (PC)-derived α-defensins constitute an integral part of...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4052980/ https://ncbi.nlm.nih.gov/pubmed/21178012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002021 |
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