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Antiviral Therapy during Primary Simian Immunodeficiency Virus Infection Fails To Prevent Acute Loss of CD4(+) T Cells in Gut Mucosa but Enhances Their Rapid Restoration through Central Memory T Cells

Gut-associated lymphoid tissue (GALT) is an early target of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) and a site for severe CD4(+) T-cell depletion. Although antiretroviral therapy (ART) is effective in suppressing HIV replication and restoring CD4(+) T cells in peri...

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Detalhes bibliográficos
Main Authors: Verhoeven, David, Sankaran, Sumathi, Silvey, Melanie, Dandekar, Satya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292978/
https://ncbi.nlm.nih.gov/pubmed/18272585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02164-07
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