Heightened Cytotoxic Responses and Impaired Biogenesis Contribute to Early Pathogenesis in the Oral Mucosa of Simian Immunodeficiency Virus-Infected Rhesus Macaques

Simian immunodeficiency virus (SIV) infection disseminated into the oropharyngeal tissues of rhesus macaques 6 weeks following intravenous inoculation. Severe local CD4(+) T-cell depletion coincided with increases in NK cell and proinflammatory biomarkers and the disruption of growth-associated gene...

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Detalhes bibliográficos
Main Authors: George, Michael D., Verhoeven, David, Sankaran, Sumathi, Glavan, Tiffany, Reay, Elizabeth, Dandekar, Satya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Microbial Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643550/
https://ncbi.nlm.nih.gov/pubmed/19091994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00265-08
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