Persistence of Gut Mucosal Innate Immune Defenses by Enteric α-Defensin Expression in the Simian Immunodeficiency Virus Model of AIDS

Gastrointestinal mucosa is an early target of HIV and a site of viral replication and severe CD4+ T-cell depletion. However, effects of HIV infection on gut mucosal innate immune defense have not been fully investigated. Intestinal Paneth cell (PC)-derived α-defensins constitute an integral part of...

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Hauptverfasser: Zaragoza, Melinda M., Sankaran, Sumathi, Canfield, Don R., Hung, Jason KS, Martinez, Enrique, Ouellette, André J., Dandekar, Satya
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052980/
https://ncbi.nlm.nih.gov/pubmed/21178012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002021
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