MZB1 is a GRP94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon ER stress

MZB1 (pERp1) is a B-cell-specific and endoplasmic reticulum (ER)-localized protein implicated in antibody secretion and integrin-mediated cell adhesion. Here, we examine the role of MZB1 in vivo by conditional gene inactivation in the mouse germline and at different stages of B lymphopoiesis. Deleti...

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Detalhes bibliográficos
Main Authors: Rosenbaum, Marc, Andreani, Virginia, Kapoor, Tanya, Herp, Simone, Flach, Henrik, Duchniewicz, Marlena, Grosschedl, Rudolf
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052763/
https://ncbi.nlm.nih.gov/pubmed/24888588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.240762.114
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