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Targeted Deletion of ER Chaperone GRP94 in the Liver Results in Injury, Repopulation of GRP94-Positive Hepatocytes, and Spontaneous Hepatocellular Carcinoma Development in Aged Mice

Hepatocellular carcinoma (HCC) often results from chronic liver injury and severe fibrosis or cirrhosis, but the underlying molecular pathogenesis is unclear. We previously reported that deletion of glucose regulated protein 94 (GRP94), a major endoplasmic reticulum chaperone, in the bone marrow and...

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Detalhes bibliográficos
Publicado no:Neoplasia
Main Authors: Chen, Wan-Ting, Ha, Dat, Kanel, Gary, Lee, Amy S.
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235012/
https://ncbi.nlm.nih.gov/pubmed/25220589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2014.07.005
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