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Targeted Deletion of ER Chaperone GRP94 in the Liver Results in Injury, Repopulation of GRP94-Positive Hepatocytes, and Spontaneous Hepatocellular Carcinoma Development in Aged Mice

Hepatocellular carcinoma (HCC) often results from chronic liver injury and severe fibrosis or cirrhosis, but the underlying molecular pathogenesis is unclear. We previously reported that deletion of glucose regulated protein 94 (GRP94), a major endoplasmic reticulum chaperone, in the bone marrow and...

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書誌詳細
出版年:Neoplasia
主要な著者: Chen, Wan-Ting, Ha, Dat, Kanel, Gary, Lee, Amy S.
フォーマット: Artigo
言語:Inglês
出版事項: Neoplasia Press 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235012/
https://ncbi.nlm.nih.gov/pubmed/25220589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2014.07.005
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