Inhibition of Egr1 expression underlies the anti-mitogenic effects of cAMP in vascular smooth muscle cells

AIMS: Cyclic AMP inhibits vascular smooth muscle cell (VSMC) proliferation which is important in the aetiology of numerous vascular diseases. The anti-mitogenic properties of cAMP in VSMC are dependent on activation of protein kinase A (PKA) and exchange protein activated by cAMP (EPAC), but the mec...

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Detalhes bibliográficos
Main Authors: Kimura, Tomomi E., Duggirala, Aparna, Hindmarch, Charles C.T., Hewer, Richard C., Cui, Mei-Zhen, Newby, Andrew C., Bond, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: Academic Press 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051994/
https://ncbi.nlm.nih.gov/pubmed/24534707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.02.001
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