Conditional Ablation of Astroglial CCL2 Suppresses CNS Accumulation of M1 Macrophages and Preserves Axons in Mice with MOG Peptide EAE

Current multiple sclerosis (MS) therapies only partially prevent chronically worsening neurological deficits, which are largely attributable to progressive loss of CNS axons. Prior studies of experimental autoimmune encephalomyelitis (EAE) induced in C57BL/6 mice by immunization with myelin oligoden...

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Hlavní autoři: Moreno, Monica, Bannerman, Peter, Ma, Joyce, Guo, Fuzheng, Miers, Laird, Soulika, Athena M., Pleasure, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051973/
https://ncbi.nlm.nih.gov/pubmed/24920622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1137-14.2014
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