Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model

Multiple sclerosis (MS) is characterized by central nervous system (CNS) inflammation, demyelination, and axonal degeneration. CXCL10 (IP-10), a chemokine for CXCR3(+) T cells, is known to regulate T cell differentiation and migration in the periphery, but effects of CXCL10 produced endogenously in...

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Main Authors: Mills Ko, Emily, Ma, Joyce H, Guo, Fuzheng, Miers, Laird, Lee, Eunyoung, Bannerman, Peter, Burns, Travis, Ko, David, Sohn, Jiho, Soulika, Athena M, Pleasure, David
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066277/
https://ncbi.nlm.nih.gov/pubmed/24924222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-11-105
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