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DNA double-strand break repair pathway choice and cancer
Since DNA double-strand breaks (DSBs) contribute to the genomic instability that drives cancer development, DSB repair pathways serve as important mechanisms for tumor suppression. Thus, genetic lesions, such as BRCA1 and BRCA2 mutations, that disrupt DSB repair are often associated with cancer susc...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4051845/ https://ncbi.nlm.nih.gov/pubmed/24746645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2014.03.014 |
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