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Tyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function
Cytotoxic T lymphocyte antigen-4 (CTLA-4) is a major negative regulatory molecule for T cell activation with a complex biology and function. CTLA-4 is known to regulate homeostatic lymphoproliferation as well as tolerance induction and has been proposed to be an important effector molecule by which...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4051436/ https://ncbi.nlm.nih.gov/pubmed/24648182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201343891 |
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