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DGCR8-Mediated Production of Canonical Micrornas Is Critical for Regulatory T Cell Function and Stability
Regulatory T cells (Treg) are integral for immune homeostasis. Here we demonstrate that canonical microRNAs (miRNAs) are required for Treg function because mice with DGCR8-deficient Treg cells spontaneously develop a scurfy-like disease. Using genetic lineage marking we show that absence of miRNAs l...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3669207/ https://ncbi.nlm.nih.gov/pubmed/23741528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066282 |
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