Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells

Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have funct...

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Bibliographic Details
Main Authors: Lombardi, Sara, Honeth, Gabriella, Ginestier, Christophe, Shinomiya, Ireneusz, Marlow, Rebecca, Buchupalli, Bharath, Gazinska, Patrycja, Brown, John, Catchpole, Steven, Liu, Suling, Barkan, Ariel, Wicha, Max, Purushotham, Anand, Burchell, Joy, Pinder, Sarah, Dontu, Gabriela
Format: Artigo
Language:Inglês
Published: Elsevier 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050343/
https://ncbi.nlm.nih.gov/pubmed/24936466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.05.005
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