Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells

Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have funct...

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Detalhes bibliográficos
Main Authors: Lombardi, Sara, Honeth, Gabriella, Ginestier, Christophe, Shinomiya, Ireneusz, Marlow, Rebecca, Buchupalli, Bharath, Gazinska, Patrycja, Brown, John, Catchpole, Steven, Liu, Suling, Barkan, Ariel, Wicha, Max, Purushotham, Anand, Burchell, Joy, Pinder, Sarah, Dontu, Gabriela
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050343/
https://ncbi.nlm.nih.gov/pubmed/24936466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.05.005
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