Nuclear accumulation of cyclin D1 following long-term fractionated exposures to low-dose ionizing radiation in normal human diploid cells

Cyclin D1 is a mitogenic sensor that responds to growth signals from the extracellular environment and regulates the G(1)-to-S cell cycle transition. When cells are acutely irradiated with a single dose of 10 Gy, cyclin D1 is degraded, causing cell cycle arrest at the G(1)/S checkpoint. In contrast,...

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Hlavní autoři: Shimura, Tsutomu, Hamada, Nobuyuki, Sasatani, Megumi, Kamiya, Kenji, Kunugita, Naoki
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049961/
https://ncbi.nlm.nih.gov/pubmed/24583467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.28139
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