Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in lowdose irradiated human fibroblasts

Here we investigated the cellular response of normal human fibroblasts to repeated exposure to low-dose radiation. In contrast to acute single radiation, low-dose fractionated radiation (FR) with 0.01 Gy/fraction or 0.05 Gy/fraction for 31 days increased in mitochondrial mass, decreased cellular lev...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Shimura, Tsutomu, Sasatani, Megumi, Kamiya, Kenji, Kawai, Hidehiko, Inaba, Yohei, Kunugita, Naoki
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823127/
https://ncbi.nlm.nih.gov/pubmed/26657292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6518
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