ATM-mediated mitochondrial damage response triggered by nuclear DNA damage in normal human lung fibroblasts

Ionizing radiation (IR) elevates mitochondrial oxidative phosphorylation (OXPHOS) in response to the energy requirement for DNA damage responses. Reactive oxygen species (ROS) released during mitochondrial OXPHOS may cause oxidative damage to mitochondria in irradiated cells. In this paper, we inves...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Shimura, Tsutomu, Sasatani, Megumi, Kawai, Hidehiko, Kamiya, Kenji, Kobayashi, Junya, Komatsu, Kenshi, Kunugita, Naoki
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788412/
https://ncbi.nlm.nih.gov/pubmed/29099268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1387697
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