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Nuclear accumulation of cyclin D1 following long-term fractionated exposures to low-dose ionizing radiation in normal human diploid cells
Cyclin D1 is a mitogenic sensor that responds to growth signals from the extracellular environment and regulates the G(1)-to-S cell cycle transition. When cells are acutely irradiated with a single dose of 10 Gy, cyclin D1 is degraded, causing cell cycle arrest at the G(1)/S checkpoint. In contrast,...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Landes Bioscience
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4049961/ https://ncbi.nlm.nih.gov/pubmed/24583467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.28139 |
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