Allele-Specific Methylation Occurs at Genetic Variants Associated with Complex Disease

We hypothesize that the phenomenon of allele-specific methylation (ASM) may underlie the phenotypic effects of multiple variants identified by Genome-Wide Association studies (GWAS). We evaluate ASM in a human population and document its genome-wide patterns in an initial screen at up to 380,678 sit...

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Autors principals: Hutchinson, John N., Raj, Towfique, Fagerness, Jes, Stahl, Eli, Viloria, Fernando T., Gimelbrant, Alexander, Seddon, Johanna, Daly, Mark, Chess, Andrew, Plenge, Robert
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049588/
https://ncbi.nlm.nih.gov/pubmed/24911414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098464
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