Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS-ERK signaling

The effects of selective PI3K and AKT inhibitors were compared in human tumor cell lines in which the pathway is dysregulated. Both caused inhibition of AKT, relief of feedback inhibition of RTKs, and growth arrest. However, only the PI3K inhibitors caused rapid induction of cell death. In seeking a...

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Autori principali: Will, Marie, Qin, Alice Can Ran, Toy, Weiyi, Yao, Zhan, Rodrik-Outmezguine, Vanessa, Schneider, Claudia, Huang, Xiaodong, Monian, Prashant, Jiang, Xuejun, de Stanchina, Elisa, Baselga, Jose, Liu, Ningshu, Chandarlapaty, Sarat, Rosen, Neal
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049524/
https://ncbi.nlm.nih.gov/pubmed/24436048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0611
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