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Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS
Approximately 200 BRAF mutant alleles have been identified in human tumours. Activating BRAF mutants cause feedback inhibition of GTP-bound RAS, are RAS-independent and signal either as active monomers (class 1) or constitutively active dimers (class 2)(1). Here we characterize a third class of BRAF...
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| Publicat a: | Nature |
|---|---|
| Autors principals: | , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5648058/ https://ncbi.nlm.nih.gov/pubmed/28783719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23291 |
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