Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS

Approximately 200 BRAF mutant alleles have been identified in human tumours. Activating BRAF mutants cause feedback inhibition of GTP-bound RAS, are RAS-independent and signal either as active monomers (class 1) or constitutively active dimers (class 2)(1). Here we characterize a third class of BRAF...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Yao, Zhan, Yaeger, Rona, Rodrik-Outmezguine, Vanessa S., Tao, Anthony, Torres, Neilawattie M., Chang, Matthew T., Drosten, Matthias, Zhao, Huiyong, Cecchi, Fabiola, Hembrough, Todd, Michels, Judith, Baumert, Hervé, Miles, Linde, Campbell, Naomi M., de Stanchina, Elisa, Solit, David B., Barbacid, Mariano, Taylor, Barry S., Rosen, Neal
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648058/
https://ncbi.nlm.nih.gov/pubmed/28783719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23291
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