Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS

Approximately 200 BRAF mutant alleles have been identified in human tumours. Activating BRAF mutants cause feedback inhibition of GTP-bound RAS, are RAS-independent and signal either as active monomers (class 1) or constitutively active dimers (class 2)(1). Here we characterize a third class of BRAF...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Nature
Autors principals: Yao, Zhan, Yaeger, Rona, Rodrik-Outmezguine, Vanessa S., Tao, Anthony, Torres, Neilawattie M., Chang, Matthew T., Drosten, Matthias, Zhao, Huiyong, Cecchi, Fabiola, Hembrough, Todd, Michels, Judith, Baumert, Hervé, Miles, Linde, Campbell, Naomi M., de Stanchina, Elisa, Solit, David B., Barbacid, Mariano, Taylor, Barry S., Rosen, Neal
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648058/
https://ncbi.nlm.nih.gov/pubmed/28783719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23291
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars