AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

Activation of the PI3K-AKT pathway in tumors is modulated by negative feedback, including mTORC1-mediated inhibition of upstream signaling. We now show that AKT inhibition induces the expression and phosphorylation of multiple receptor tyrosine kinases (RTKs). In a wide spectrum of tumor types, inhi...

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Hlavní autoři: Chandarlapaty, Sarat, Sawai, Ayana, Scaltriti, Maurizio, Rodrik-Outmezguine, Vanessa, Grbovic-Huezo, Olivera, Serra, Violeta, Majumder, Pradip K., Baselga, Jose, Rosen, Neal
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025058/
https://ncbi.nlm.nih.gov/pubmed/21215704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.10.031
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