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Negative feedback and adaptive resistance to the targeted therapy of cancer

Mutational activation of growth factor signaling pathways is commonly observed and often necessary for oncogenic transformation. Under physiologic conditions, these pathways are subject to tight regulation via negative feedback which limits the extent and duration of signaling events after physiolog...

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Detalhes bibliográficos
Autor principal: Chandarlapaty, Sarat
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351275/
https://ncbi.nlm.nih.gov/pubmed/22576208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0018
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