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Negative feedback and adaptive resistance to the targeted therapy of cancer
Mutational activation of growth factor signaling pathways is commonly observed and often necessary for oncogenic transformation. Under physiologic conditions, these pathways are subject to tight regulation via negative feedback which limits the extent and duration of signaling events after physiolog...
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3351275/ https://ncbi.nlm.nih.gov/pubmed/22576208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0018 |
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