Selective methylation of histone H3 variant H3.1 regulates heterochromatin replication

Histone variants have been proposed to act as determinants for post-translational modifications (PTM) with widespread regulatory functions. In this report, we identify a histone-modifying enzyme that selectively methylates the replication-dependent histone H3 variant H3.1. The crystal structure of t...

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Autores principales: Jacob, Yannick, Bergamin, Elisa, Donoghue, Mark T.A., Mongeon, Vanessa, LeBlanc, Chantal, Voigt, Philipp, Underwood, Charles J., Brunzelle, Joseph S., Michaels, Scott D., Reinberg, Danny, Couture, Jean-François, Martienssen, Robert A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049228/
https://ncbi.nlm.nih.gov/pubmed/24626927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1248357
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