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Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases

Multiple pathways prevent DNA replication from occurring more than once per cell cycle1. These pathways block re-replication by strictly controlling the activity of pre-replication complexes, which assemble at specific sites in the genome called origins. Here we show that mutations in the homologous...

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Autors principals: Jacob, Yannick, Stroud, Hume, LeBlanc, Chantal, Feng, Suhua, Zhou, Luting, Caro, Elena, Hassel, Christiane, Gutierrez, Crisanto, Michaels, Scott D., Jacobsen, Steven E.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964344/
https://ncbi.nlm.nih.gov/pubmed/20631708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09290
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