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Constitutively active NDR1-PIF kinase functions independent of MST1 and hMOB1 signalling

The human MST1/hMOB1/NDR1 tumour suppressor cascade regulates important cellular processes, such as centrosome duplication. hMOB1/NDR1 complex formation appears to be essential for NDR1 activation by autophosphorylation on Ser281 and hydrophobic motif (HM) phosphorylation at Thr444 by MST1. To disse...

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Detalles Bibliográficos
Autores principales: Cook, Dorthe, Hoa, Lily Y., Gomez, Valenti, Gomez, Marta, Hergovich, Alexander
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049220/
https://ncbi.nlm.nih.gov/pubmed/24747552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2014.04.011
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