Discovery and saturation analysis of cancer genes across 21 tumor types

While a few cancer genes are mutated in a high proportion of tumors of a given type (>20%), most are mutated at intermediate frequencies (2–20%). To explore the feasibility of creating a comprehensive catalog of cancer genes, we analyzed somatic point mutations in exome sequence from 4,742 tumor-...

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Bibliografiske detaljer
Main Authors: Lawrence, Michael S., Stojanov, Petar, Mermel, Craig H., Garraway, Levi A., Golub, Todd R., Meyerson, Matthew, Gabriel, Stacey B., Lander, Eric S., Getz, Gad
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048962/
https://ncbi.nlm.nih.gov/pubmed/24390350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12912
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