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Gating charge movement precedes ionic current activation in hERG channels

We recently reported gating currents recorded from hERG channels expressed in mammalian TSA cells and assessed the kinetics at different voltages. We detected 2 distinct components of charge movement with the bulk of the charge being carried by a slower component. Here we compare our findings in TSA...

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Autori principali: Goodchild, Samuel J, Fedida, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048346/
https://ncbi.nlm.nih.gov/pubmed/24126078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.26775
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