Antigenic and 3D structural characterization of soluble X4 and hybrid X4-R5 HIV-1 Env trimers

BACKGROUND: HIV-1 is decorated with trimeric glycoprotein spikes that enable infection by engaging CD4 and a chemokine coreceptor, either CCR5 or CXCR4. The variable loop 3 (V3) of the HIV-1 envelope protein (Env) is the main determinant for coreceptor usage. The predominant CCR5 using (R5) HIV-1 En...

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Autores principales: Arnold, Philipp, Himmels, Patricia, Weiß, Svenja, Decker, Tim-Michael, Markl, Jürgen, Gatterdam, Volker, Tampé, Robert, Bartholomäus, Patrick, Dietrich, Ursula, Dürr, Ralf
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048260/
https://ncbi.nlm.nih.gov/pubmed/24884925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-11-42
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