Quantitative multi-parametric evaluation of centrosome declustering drugs: centrosome amplification, mitotic phenotype, cell cycle and death

Unlike normal cells, cancer cells contain amplified centrosomes and rely on centrosome clustering mechanisms to form a pseudobipolar spindle that circumvents potentially fatal spindle multipolarity (MP). Centrosome clustering also promotes low-grade chromosome missegregation, which can drive maligna...

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Detaylı Bibliyografya
Asıl Yazarlar: Ogden, A, Cheng, A, Rida, P C G, Pannu, V, Osan, R, Clewley, R, Aneja, R
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2014
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047924/
https://ncbi.nlm.nih.gov/pubmed/24787016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.164
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