A novel microtubule-modulating noscapinoid triggers apoptosis by inducing spindle multipolarity via centrosome amplification and declustering

We have previously shown that a non-toxic noscapinoid, EM011 binds tubulin without altering its monomer/polymer ratio. EM011 is more active than the parent molecule, noscapine, in inducing G2/M arrest, inhibiting cellular proliferation and tumor growth in various human xenograft models. However, the...

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Detalhes bibliográficos
Main Authors: Karna, P, Rida, P C G, Pannu, V, Gupta, K K, Dalton, W B, Joshi, H, Yang, V W, Zhou, J, Aneja, R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131906/
https://ncbi.nlm.nih.gov/pubmed/21052096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.133
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