Induction of robust de novo centrosome amplification, high-grade spindle multipolarity and metaphase catastrophe: a novel chemotherapeutic approach

Centrosome amplification (CA) and resultant chromosomal instability have long been associated with tumorigenesis. However, exacerbation of CA and relentless centrosome declustering engender robust spindle multipolarity (SM) during mitosis and may induce cell death. Recently, we demonstrated that a n...

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Detalhes bibliográficos
Main Authors: Pannu, V, Rida, P C G, Ogden, A, Clewley, R, Cheng, A, Karna, P, Lopus, M, Mishra, R C, Zhou, J, Aneja, R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406581/
https://ncbi.nlm.nih.gov/pubmed/22785532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.82
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