High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy

Inhibition of distinct ubiquitin E3 ligases might represent a powerful therapeutic tool. ITCH is a HECT domain-containing E3 ligase that promotes the ubiquitylation and degradation of several proteins, including p73, p63, c-Jun, JunB, Notch and c-FLIP, thus affecting cell fate. Accordingly, ITCH dep...

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Detalhes bibliográficos
Main Authors: Rossi, M, Rotblat, B, Ansell, K, Amelio, I, Caraglia, M, Misso, G, Bernassola, F, Cavasotto, C N, Knight, R A, Ciechanover, A, Melino, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047876/
https://ncbi.nlm.nih.gov/pubmed/24787015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.113
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