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Endothelial PINK1 mediates the protective effects of NLRP3 deficiency during lethal oxidant injury

High levels of inspired oxygen, hyperoxia, are frequently used in patients with acute respiratory failure. Hyperoxia can exacerbate acute respiratory failure, which has high mortality and no specific therapies. We identified a novel roles for PINK1 (PTEN-induced putative kinase 1), a mitochondrial p...

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Detalhes bibliográficos
Main Authors: Zhang, Yi, Sauler, Maor, Shinn, Amanda S., Gong, Huan, Haslip, Maria, Shan, Peiying, Mannam, Praveen, Lee, Patty J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047670/
https://ncbi.nlm.nih.gov/pubmed/24778451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400653
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