Alternative Mammalian Target of Rapamycin (mTOR) Signal Activation in Sorafenib-resistant Hepatocellular Carcinoma Cells Revealed by Array-based Pathway Profiling

Sorafenib is a multi-kinase inhibitor that has been proven effective for the treatment of unresectable hepatocellular carcinoma (HCC). However, its precise mechanisms of action and resistance have not been well established. We have developed high-density fluorescence reverse-phase protein arrays and...

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Detalhes bibliográficos
Main Authors: Masuda, Mari, Chen, Wei-Yu, Miyanaga, Akihiko, Nakamura, Yuka, Kawasaki, Kumiko, Sakuma, Tomohiro, Ono, Masaya, Chen, Chi-Long, Honda, Kazufumi, Yamada, Tesshi
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047464/
https://ncbi.nlm.nih.gov/pubmed/24643969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M113.033845
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