GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia

Transient leukemia (TL) is evident in 5–10% of all neonates with Down syndrome (DS) and associated with N-terminal truncating GATA1-mutations (GATA1s). Here we report that TL cell clones generate abundant eosinophils in a substantial fraction of patients. Sorted eosinophils from patients with TL and...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Maroz, Aliaksandra, Stachorski, Lena, Emmrich, Stephan, Reinhardt, Katarina, Xu, Jian, Shao, Zhen, Käbler, Sebastian, Dertmann, Tobias, Hitzler, Johann, Roberts, Irene, Vyas, Paresh, Juban, Gaetan, Hennig, Christian, Hansen, Gesine, Li, Zhe, Orkin, Stuart, Reinhardt, Dirk, Klusmann, Jan-Henning
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047213/
https://ncbi.nlm.nih.gov/pubmed/24336126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.373
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky