miR-99a/100∼125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGFβ and Wnt signaling

Although regulation of stem cell homeostasis by microRNAs (miRNAs) is well studied, it is unclear how individual miRNAs genomically encoded within an organized polycistron can interact to induce an integrated phenotype. miR-99a/100, let-7, and miR-125b paralogs are encoded in two tricistrons on huma...

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Main Authors: Emmrich, Stephan, Rasche, Mareike, Schöning, Jennifer, Reimer, Christina, Keihani, Sarva, Maroz, Aliaksandra, Xie, Ying, Li, Zhe, Schambach, Axel, Reinhardt, Dirk, Klusmann, Jan-Henning
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2014
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003278/
https://ncbi.nlm.nih.gov/pubmed/24736844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.233791.113
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