lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling

De novo and acquired resistance, largely attributed to genetic alterations, are barriers to effective anti-EGFR therapy. We generated cetuximab-resistant cells following prolonged cetuximab exposure to cetuximab-sensitive colorectal cancer cells in three-dimensional culture. Through whole exome sequ...

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Pubblicato in:Nat Med
Autori principali: Lu, Yuanyuan, Zhao, Xiaodi, Liu, Qi, Li, Cunxi, Graves-Deal, Ramona, Cao, Zheng, Singh, Bhuminder, Franklin, Jeffrey L., Wang, Jing, Hu, Huaying, Wei, Tianying, Yang, Mingli, Yeatman, Timothy J., Lee, Ethan, Saito-Diaz, Kenyi, Hinger, Scott, Patton, James G., Chung, Christine H., Emmrich, Stephan, Klusmann, Jan-Henning, Fan, Daiming, Coffey, Robert J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961502/
https://ncbi.nlm.nih.gov/pubmed/29035371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4424
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