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GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia
Transient leukemia (TL) is evident in 5–10% of all neonates with Down syndrome (DS) and associated with N-terminal truncating GATA1-mutations (GATA1s). Here we report that TL cell clones generate abundant eosinophils in a substantial fraction of patients. Sorted eosinophils from patients with TL and...
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| Autori principali: | , , , , , , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4047213/ https://ncbi.nlm.nih.gov/pubmed/24336126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.373 |
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