GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia

Transient leukemia (TL) is evident in 5–10% of all neonates with Down syndrome (DS) and associated with N-terminal truncating GATA1-mutations (GATA1s). Here we report that TL cell clones generate abundant eosinophils in a substantial fraction of patients. Sorted eosinophils from patients with TL and...

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Autori principali: Maroz, Aliaksandra, Stachorski, Lena, Emmrich, Stephan, Reinhardt, Katarina, Xu, Jian, Shao, Zhen, Käbler, Sebastian, Dertmann, Tobias, Hitzler, Johann, Roberts, Irene, Vyas, Paresh, Juban, Gaetan, Hennig, Christian, Hansen, Gesine, Li, Zhe, Orkin, Stuart, Reinhardt, Dirk, Klusmann, Jan-Henning
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047213/
https://ncbi.nlm.nih.gov/pubmed/24336126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.373
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