BM-1197: A Novel and Specific Bcl-2/Bcl-xL Inhibitor Inducing Complete and Long-Lasting Tumor Regression In Vivo

Bcl-2 and Bcl-xL are critical regulators of apoptosis that are overexpressed in a variety of human cancers and pharmacological inhibition of Bcl-2 and Bcl-xL represents a promising strategy for cancer treatment. Using a structure-based design approach, we have designed BM-1197 as a potent and effica...

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Detaylı Bibliyografya
Asıl Yazarlar: Bai, Longchuan, Chen, Jianfang, McEachern, Donna, Liu, Liu, Zhou, Haibin, Aguilar, Angelo, Wang, Shaomeng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047118/
https://ncbi.nlm.nih.gov/pubmed/24901320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099404
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