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Pyroptosis drives CD4 T-cell depletion in HIV-1 infection
The pathway causing CD4 T-cell death in HIV-infected hosts remains poorly understood. Apoptosis has been proposed as the key mechanism for CD4 T-cell loss. We now show that caspase-3-mediated apoptosis accounts for the death of only a small fraction of productively infected cells. The remaining >...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4047036/ https://ncbi.nlm.nih.gov/pubmed/24356306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12940 |
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