Pyroptosis drives CD4 T-cell depletion in HIV-1 infection

The pathway causing CD4 T-cell death in HIV-infected hosts remains poorly understood. Apoptosis has been proposed as the key mechanism for CD4 T-cell loss. We now show that caspase-3-mediated apoptosis accounts for the death of only a small fraction of productively infected cells. The remaining >...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Doitsh, Gilad, Galloway, Nicole LK, Geng, Xin, Yang, Zhiyuan, Monroe, Kathryn M., Zepeda, Orlando, Hunt, Peter W., Hatano, Hiroyu, Sowinski, Stefanie, Muñoz-Arias, Isa, Greene, Warner C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047036/
https://ncbi.nlm.nih.gov/pubmed/24356306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12940
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi