Pyroptosis drives CD4 T-cell depletion in HIV-1 infection

The pathway causing CD4 T-cell death in HIV-infected hosts remains poorly understood. Apoptosis has been proposed as the key mechanism for CD4 T-cell loss. We now show that caspase-3-mediated apoptosis accounts for the death of only a small fraction of productively infected cells. The remaining >...

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Bibliografiske detaljer
Main Authors: Doitsh, Gilad, Galloway, Nicole LK, Geng, Xin, Yang, Zhiyuan, Monroe, Kathryn M., Zepeda, Orlando, Hunt, Peter W., Hatano, Hiroyu, Sowinski, Stefanie, Muñoz-Arias, Isa, Greene, Warner C.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047036/
https://ncbi.nlm.nih.gov/pubmed/24356306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12940
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