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Substrate preference of the HIF-prolyl hydroxylase-2 (PHD2) and substrate-induced conformational change
HIF prolyl-4-hydroxylase 2 (PHD2) is a non-heme Fe, 2-oxoglutarate (2OG) dependent dioxygenase that regulates the hypoxia inducible transcription factor (HIF) by hydroxylating two conserved prolyl residues in N-terminal oxygen degradation domain (NODD) and C-terminal oxygen degradation domain (CODD)...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4046702/ https://ncbi.nlm.nih.gov/pubmed/23787140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2013.05.006 |
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