Small GTPase Rab14 down-regulates UT-A1 urea transport activity through enhanced clathrin-dependent endocytosis

The UT-A1 urea transporter plays an important role in the urinary concentration mechanism. However, the molecular mechanisms regarding UT-A1 trafficking, endocytosis, and degradation are still unclear. In this study, we identified the small GTPase Rab14 as a binding partner to the C terminus of UT-A...

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Bibliografiske detaljer
Main Authors: Su, Hua, Liu, Bingchen, Fröhlich, Otto, Ma, Heping, Sands, Jeff M., Chen, Guangping
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2013
Fag:
Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046183/
https://ncbi.nlm.nih.gov/pubmed/23796783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-229294
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