Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma

BACKGROUND: Arsenic trioxide has been demonstrated as an effective anti-cancer drug against leukemia and solid tumors both in vitro and in vivo. However, recent phase II trials demonstrated that single agent arsenic trioxide was poorly effective against hepatocellular carcinoma (HCC), which might be...

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Bibliografiske detaljer
Main Authors: Zheng, Tongsen, Yin, Dalong, Lu, Zhaoyang, Wang, Jiabei, Li, Yuejin, Chen, Xi, Liang, Yingjian, Song, Xuan, Qi, Shuyi, Sun, Boshi, Xie, Changming, Meng, Xianzhi, Pan, Shangha, Liu, Jiaren, Jiang, Hongchi, Liu, Lianxin
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046148/
https://ncbi.nlm.nih.gov/pubmed/24884809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-133
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